Publisher: Cambridge University Press
E-ISSN: 1475-2662|99|3|550-558
ISSN: 0007-1145
Source: British Journal of Nutrition, Vol.99, Iss.3, 2008-03, pp. : 550-558
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Abstract
Epidemiological studies suggest an inverse association between folic acid intake and colorectal cancer risk. Conversely, conventional treatment of existing tumours includes the use of folate antagonists. This suggests that the level of exposure to folate and its timing in relation to stage of tumorigenesis may be critical in determining outcomes. We hypothesised that folic acid depletion
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