Immunological activities of a lymphocyte mitogen isolated from coenurus fluid of Taenia multiceps (Cestoda)

Author： Rakha N.K   Dixon J.B.   Carter S.D.  

Publisher： Edp Sciences

E-ISSN： 1776-1042|4|1|9-16

ISSN： 1252-607x

Source： Parasite, Vol.4, Iss.1, 2014-09, pp. : 9-16

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Abstract

The purification of a mitogen from Taenia multiceps coenurus fluid has been previously reported. In the present study, this activity, which was independent of endotoxin, stimulated the expression of lymphocyte IL-2 and Fc receptors, enhanced mitotic response to phytohaemagglutinin and concanavalin A and antagonised the previously described suppressive effects of the macrophage modifying fraction of coenurus fluid. The mitogen also increased peritoneal macrophage count and viability, Fc receptor expression and Fc receptor-mediated phagocytosis. The mitogenic activity could be destroyed by a combination of protease and amylase, but not by either enzyme alone. It is suggested that the mitogen forms part of a homeostatic mechanism for the preservation of a balanced host-parasite relationship.

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