Non specific resistance against malaria pre-erythrocytic stages: involvement of acute phase proteins

Author： Pied S.   Tabone M.-D   Chatellier G.   Marussig M.   Jarde C.   Nosten F.   Mazier D.  

Publisher： Edp Sciences

E-ISSN： 1776-1042|2|3|263-268

ISSN： 1252-607x

Source： Parasite, Vol.2, Iss.3, 2014-09, pp. : 263-268

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Abstract

Levels of different acute phase proteins were compared in sera from parasitaemic and non-parasitaemic women living in a Plasmodium falciparum endemic area of Thailand. The ability of their sera to interfere with hepatic stage development of the parasite was examined. Correlations were found between levels of α- 1 antitrypsin, α-2 macroglobulin, hemopexin and the potential of sera to block hepatocyte invasion by the sporozoite.

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