Author： Fokkens Michael Klärner Frank-Gerrit Schrader Thomas
Publisher： MDPI
E-ISSN： 1424-8220|6|8|860-873
ISSN： 1424-8220
Source： Sensors, Vol.6, Iss.8, 2006-08, pp. : 860-873
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the 1H NMR spectrum. Nucleoside drugs can therefore be detected with high selectivity in the presence of their phosphorylated pendants or nucleic acids.
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