Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

Author： de Sousa Damião Pergentino   Schefer Renata Rabelo   Brocksom Ursula   Brocksom Timothy John  

Publisher： MDPI

E-ISSN： 1420-3049|11|2|148-155

ISSN： 1420-3049

Source： Molecules, Vol.11, Iss.2, 2006-03, pp. : 148-155

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Abstract

A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5-methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.

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