Novel Heteroatom-containing Vitamin D3 Analogs: Efficient Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-lactam

Author: Kato Yuko   Hashimoto Yuichi   Nagasawa Kazuo  

Publisher: MDPI

E-ISSN: 1420-3049|8|6|488-499

ISSN: 1420-3049

Source: Molecules, Vol.8, Iss.6, 2003-06, pp. : 488-499

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Abstract

Vitamin D3 and its synthetic analogs are promising compounds for controlling various types of cell differentiation. In this article, we describe the synthesis of novel vitamin D3 analogs containing heteroatoms in their side chains – so-called vitamin D3 lactam analogs – via 1,3-dipolar cycloaddition reaction as a key step.

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