Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa

Author： Jung Mankil   Park Moonsoo  

Publisher： MDPI

E-ISSN： 1420-3049|12|9|2130-2139

ISSN： 1420-3049

Source： Molecules, Vol.12, Iss.9, 2007-09, pp. : 2130-2139

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Abstract

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).

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