Author： Yokoyama Kazushige Cho Hyunah Cullen Sean P. Kowalik Matthew Briglio Nicole M. Hoops Harold J. Zhao Zhouying Carpenter Michael A.
Publisher： MDPI
E-ISSN： 1422-0067|10|5|2348-2366
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.10, Iss.5, 2009-05, pp. : 2348-2366
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Abstract
Aβ1–40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogenesis of Aβ (a hallmark of Alzheimer’s disease). We examined this reversible color change by microscopic investigations. AFM images on graphite surfaces revealed the morphology of Aβ aggregates with gold colloids. TEM images clearly demonstrate the correspondence between spectroscopic features and conformational changes of the gold colloid.
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