Author： Bochud Murielle Rousson Valentin
Publisher： MDPI
E-ISSN： 1660-4601|7|3|711-728
ISSN： 1660-4601
Source： International Journal of Environmental Research and Public Health, Vol.7, Iss.3, 2010-02, pp. : 711-728
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Abstract
Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a “Mendelian randomization” approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.
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