Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation, Wound Healing and Bone Formation

Author: Stanford Clark M.  

Publisher: MDPI

E-ISSN: 1422-0067|11|1|354-369

ISSN: 1422-0067

Source: International Journal of Molecular Sciences, Vol.11, Iss.1, 2010-01, pp. : 354-369

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Abstract

Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces.

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