Author： Halpern Bruno Oliveira Eduardo S. L. Faria André M. Halpern Alfredo de Melo Maria Edna Cercato Cintia Mancini Marcio C.
Publisher： MDPI
E-ISSN： 1424-8247|3|8|2398-2415
ISSN： 1424-8247
Source： Pharmaceuticals, Vol.3, Iss.8, 2010-07, pp. : 2398-2415
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use. Drugs combinations can be an option for its treatment but, although widely used in clinical practice, very few data are available in literature for its validation. Our review focuses on the rationale for their use, with advantages and disadvantages; on combinations often used, with or without studies; and on new perspectives of combinations being studied mainly by the pharmaceutical industry.
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