Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

Author： Gärtner Andrea   Ohlendorf Birgit   Schulz Dirk   Zinecker Heidi   Wiese Jutta   Imhoff Johannes F.  

Publisher： MDPI

E-ISSN： 1660-3397|9|1|98-108

ISSN： 1660-3397

Source： Marine Drugs, Vol.9, Iss.1, 2011-01, pp. : 98-108

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Abstract

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.

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