Antifungal Activity of Denture Soft Lining Material Modified by Silver Nanoparticles—A Pilot Study

Author： Chladek Grzegorz   Mertas Anna   Barszczewska-Rybarek Izabela   Nalewajek Teresa   Żmudzki Jarosław   Król Wojciech   Łukaszczyk Jan  

Publisher： MDPI

E-ISSN： 1422-0067|12|7|4735-4744

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.12, Iss.7, 2011-07, pp. : 4735-4744

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Abstract

Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors are the cause of mucosal infections. The microorganism that most frequently colonizes soft liner materials is Candida albicans. Colonization occurs on the surface of materials and within materials. A solution to this problem might involve modification of soft liner materials with silver nanoparticles (AgNPs). In this article, we present results showing the antifungal efficacy of silicone soft lining materials modified with AgNPs. The modification process was conducted by dissolving both material components (base and catalyst) in a colloidal solution of AgNPs and evaporating the solvent. Composites with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) were examined. The in vitro antifungal efficacy (AFE) of composite samples was 16.3% to 52.5%.

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