Biochemistry of Bacterial Multidrug Efflux Pumps

Author: Kumar Sanath   Varela Manuel F.  

Publisher: MDPI

E-ISSN: 1422-0067|13|4|4484-4495

ISSN: 1422-0067

Source: International Journal of Molecular Sciences, Vol.13, Iss.4, 2012-04, pp. : 4484-4495

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Abstract

Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mechanism for bacterial pathogen drug resistance. Therefore, because of their overwhelming presence in bacterial pathogens, these active multi-drug efflux mechanisms remain a major area of intense study, so that ultimately measures may be discovered to inhibit these active multi-drug efflux pumps.

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