An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

Author： Huang Zhibin   Zhao Qian   Chen Gang   Wang Huiyuan   Lin Wei   Xu Lexing   Liu Hongtao   Wang Juxian   Shi Daqing   Wang Yucheng  

Publisher： MDPI

E-ISSN： 1420-3049|17|11|12704-12717

ISSN： 1420-3049

Source： Molecules, Vol.17, Iss.11, 2012-10, pp. : 12704-12717

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Abstract

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

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