New Dimeric Members of the Phomoxanthone Family: Phomolactonexanthones A, B and Deacetylphomoxanthone C Isolated from the Fungus Phomopsis sp.

Author: Ding Bo   Yuan Jie   Huang Xishan   Wen Weitao   Zhu Xu   Liu Yayue   Li Hanxiang   Lu Yongjun   He Lei   Tan Hongmei   She Zhigang  

Publisher: MDPI

E-ISSN: 1660-3397|11|12|4961-4972

ISSN: 1660-3397

Source: Marine Drugs, Vol.11, Iss.12, 2013-12, pp. : 4961-4972

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Abstract

Three new phomoxanthone compounds, phomolactonexanthones A (1), B (2) and deacetylphomoxanthone C (3), along with five known phomoxanthones, including dicerandrol A (4), dicerandrol B (5), dicerandrol (6), deacetylphomoxanthone B (7) and penexanthone A (8), were isolated in the metabolites of the fungus Phomopsis sp. HNY29-2B, which was isolated from the mangrove plants. The structures of compounds 13 were established on the basis of spectroscopic analysis. All compounds were evaluated against four human cancer cell lines including human breast MDA-MB-435, human colon HCT-116, human lung Calu-3 and human liver Huh7 by MTT assay. The compounds 4, 5, 7 and 8 showed cyctotoxic activities against tested cancer cell lines (IC50 < 10 μM).

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