Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors

Author： Ji Xing-Yue   Wang Hui-Qiang   Hao Lan-Hu   He Wei-Ying   Gao Rong-Mei   Li Yan-Ping   Li Yu-Huan   Jiang Jian-Dong   Li Zhuo-Rong  

Publisher： MDPI

E-ISSN： 1420-3049|18|3|3630-3640

ISSN： 1420-3049

Source： Molecules, Vol.18, Iss.3, 2013-03, pp. : 3630-3640

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Abstract

A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4-bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8–12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.

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