Author： Chen Jui-Chieh Chang Yi-Wen Hong Chih-Chen Yu Yang-Hao Su Jen-Liang
Publisher： MDPI
E-ISSN： 1422-0067|14|1|88-107
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.14, Iss.1, 2012-12, pp. : 88-107
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Vascular endothelial growth factor C (VEGF-C) has been identified as a multifaceted factor participating in the regulation of tumor angiogenesis and lymphangiogenesis. VEGF-C is not only expressed in endothelial cells, but also in tumor cells. VEGF-C signaling is important for progression of various cancer types through both VEGF receptor-2 (VEGFR-2) and VEGF receptor-3 (VEGFR-3). Likewise, both receptors are expressed mainly on endothelial cells, but also expressed in tumor cells. The dimeric VEGF-C undergoes a series of proteolytic cleavage steps that increase the protein binding affinity to VEGFR-3; however, only complete processing, removing both the
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