Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients

Author： Fischer Sigrid G. L.   Perez Roberto S. G. M.   Nouta Jan   Zuurmond Wouter W. A.   Scheffer Peter G.  

Publisher： MDPI

E-ISSN： 1422-0067|14|4|7784-7794

ISSN： 1422-0067

Source： International Journal of Molecular Sciences, Vol.14, Iss.4, 2013-04, pp. : 7784-7794

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA damage (8-hydroxy-2-deoxyguanosine) were measured in nine patients (mean age 50.1 ± 17.1 years) with short term CRPS-1 (median 3 months) and nine age and sex matched healthy volunteers (mean age 49.3 ± 16.8 years) to assess and compare the level of oxidative stress. No differences were found in plasma between CRPS patients and healthy volunteers for malondialdehyde (5.2 ± 0.9 μmol/L vs. 5.4 ± 0.5 μmol/L) F2-isoprostanes (83.9 ± 18.7 pg/mL vs. 80.5 ± 12.3 pg/mL) and 8-hydroxy-2-deoxyguanosine (92.6 ± 25.5 pmol/L vs. 86.9 ± 19.0 pmol/L). Likewise, in urine, no differences were observed between CRPS patients and healthy volunteers for F2-isoprostanes (117 ng/mmol, IQR 54.5–124.3 vs. 85 ng/mmol, IQR 55.5–110) and 8-hydroxy-2-deoxyguanosine (1.4 ± 0.7 nmol/mmol vs. 1.4 ± 0.5 nmol/mmol). Our data show no elevation of systemic markers of oxidative stress in CRPS patients compared to matched healthy volunteers. Future research should focus on local sampling methods of oxidative stress with adequate patient selection based on CRPS phenotype and lifestyle.

Related content

The Role of hOGG1 C1245G Polymorphism in the Susceptibility to Lupus Nephritis and Modulation of the Plasma 8-OHdG in Patients with Systemic Lupus Erythematosus †

By Lee Hui-Ting   Lin Chen-Sung   Lee Chyou-Shen   Tsai Chang-Youh   Wei Yau-Huei  

International Journal of Molecular Sciences, Vol. 16, Iss. 2, 2015-02 ,pp. : 3757-3768 (12)

MDPI

Access to resources Recommend Favorite

Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

By Borrego Silvia   Vazquez Antonio   Dasí Francisco   Cerdá Concha   Iradi Antonio   Tormos Carmen   Sánchez Julia M.   Bagán Leticia   Boix Javier   Zaragoza Cristóbal   Camps Jordi   Sáez Guillermo  

International Journal of Molecular Sciences, Vol. 14, Iss. 2, 2013-02 ,pp. : 3467-3486 (20)

MDPI

Access to resources Recommend Favorite

Isoprostanes-Biomarkers of Lipid Peroxidation: Their Utility in Evaluating Oxidative Stress and Analysis

By Janicka Monika   Kot-Wasik Agata   Kot Jacek   Namieśnik Jacek  

International Journal of Molecular Sciences, Vol. 11, Iss. 11, 2010-11 ,pp. : 4631-4659 (29)

MDPI

Access to resources Recommend Favorite

Streptozotocin-Induced Cytotoxicity, Oxidative Stress and Mitochondrial Dysfunction in Human Hepatoma HepG2 Cells

By Raza Haider   John Annie  

International Journal of Molecular Sciences, Vol. 13, Iss. 5, 2012-05 ,pp. : 5751-5767 (17)

MDPI

Access to resources Recommend Favorite

Mammalian Metallothionein-2A and Oxidative Stress

By Ling Xue-Bin   Wei Hong-Wei   Wang Jun   Kong Yue-Qiong   Wu Yu-You   Guo Jun-Li   Li Tian-Fa   Li Ji-Ke  

International Journal of Molecular Sciences, Vol. 17, Iss. 9, 2016-09 ,pp. : 1483-1483 (1)

MDPI

Access to resources Recommend Favorite