Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Author： D’Souza Gypsyamber Kluz Nicole Wentz Alicia Youngfellow Renee M. Griffioen Anne Stammer Emily Guo Yingshi Xiao Weihong Gillison Maura L.

Publisher： MDPI

E-ISSN： 2072-6694|6|3|1691-1704

ISSN： 2072-6694

Source： Cancers, Vol.6, Iss.3, 2014-08, pp. : 1691-1704

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Abstract

Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18–25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10–3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06–2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man.