Author: de Freitas Thiago Aley Brites Palazzo Roberta Passos de Andrade Fabiana Michelsen Reichert César Luis Pechansky Flávio Kessler Félix de Farias Caroline Brunetto de Andrade Gisele Gomes Leistner-Segal Sandra Maluf Sharbel Weidner
Publisher: MDPI
E-ISSN: 1660-4601|11|10|10003-10015
ISSN: 1660-4601
Source: International Journal of Environmental Research and Public Health, Vol.11, Iss.10, 2014-09, pp. : 10003-10015
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Recent research suggests that crack cocaine use alters systemic biochemical markers, like oxidative damage and inflammation markers, but very few studies have assessed the potential effects of crack cocaine at the cellular level. We assessed genome instability by means of the comet assay and the cytokinesis-block micronucleus technique in crack cocaine users at the time of admission to a rehabilitation clinic and at two times after the beginning of withdrawal. Thirty one active users of crack cocaine and forty control subjects were evaluated. Comparison between controls and crack cocaine users at the first analysis showed significant differences in the rates of DNA damage (
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