Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan

Author: Ji Yuelong   Kong Xiangyi   Wang Guoying   Hong Xiumei   Xu Xin   Chen Zhu   Bartell Tami   Xu Xiping   Tang Genfu   Hou Fanfan   Huo Yong   Wang Xiaobin   Wang Binyan  

Publisher: MDPI

E-ISSN: 2072-6643|6|12|5900-5914

ISSN: 2072-6643

Source: Nutrients, Vol.6, Iss.12, 2014-12, pp. : 5900-5914

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Abstract

Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10–66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

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