Author: Gutiérrez Gerónimo Rodríguez Sabrina M. de Brogniez Alix Gillet Nicolas Golime Ramarao Burny Arsène Jaworski Juan-Pablo Alvarez Irene Vagnoni Lucas Trono Karina Willems Luc
Publisher: MDPI
E-ISSN: 1999-4915|6|6|2416-2427
ISSN: 1999-4915
Source: Viruses, Vol.6, Iss.6, 2014-06, pp. : 2416-2427
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related δ-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of δ-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.
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