Penicibrocazines A–E, Five New Sulfide Diketopiperazines from the Marine-Derived Endophytic Fungus Penicillium brocae

Author： Meng Ling-Hong   Zhang Peng   Li Xiao-Ming   Wang Bin-Gui  

Publisher： MDPI

E-ISSN： 1660-3397|13|1|276-287

ISSN： 1660-3397

Source： Marine Drugs, Vol.13, Iss.1, 2015-01, pp. : 276-287

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A–E (1–5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2–6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL.

Related content

Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S

By Gao Shu-Shan   Li Xiao-Ming   Du Feng-Yu   Li Chun-Shun   Proksch Peter   Wang Bin-Gui  

Marine Drugs, Vol. 9, Iss. 1, 2010-12 ,pp. : 59-70 (12)

MDPI

Access to resources Recommend Favorite

Aniquinazolines A–D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans

By An Chun-Yan   Li Xiao-Ming   Li Chun-Shun   Wang Ming-Hui   Xu Gang-Ming   Wang Bin-Gui  

Marine Drugs, Vol. 11, Iss. 7, 2013-07 ,pp. : 2682-2694 (13)

MDPI

Access to resources Recommend Favorite

Quinazolin-4-one Coupled with Pyrrolidin-2-iminium Alkaloids from Marine-Derived Fungus Penicillium aurantiogriseum

By Song Fuhang   Ren Biao   Yu Ke   Chen Caixia   Guo Hui   Yang Na   Gao Hong   Liu Xueting   Liu Mei   Tong Yaojun   Dai Huanqin   Bai Hua   Wang Jidong   Zhang Lixin  

Marine Drugs, Vol. 10, Iss. 6, 2012-06 ,pp. : 1297-1306 (10)

MDPI

Access to resources Recommend Favorite

Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

By Li Yongxin   Xu Ying   Liu Lingli   Han Zhuang   Lai Pok Yui   Guo Xiangrong   Zhang Xixiang   Lin Wenhan   Qian Pei-Yuan  

Marine Drugs, Vol. 10, Iss. 2, 2012-02 ,pp. : 319-328 (10)

MDPI

Access to resources Recommend Favorite

Five Sesquiterpenoids from a Marine-Derived Fungus Aspergillus sp. Isolated from a Gorgonian Dichotella gemmacea

By Wei Mei-Yan   Wang Chang-Yun   Liu Qing-Ai   Shao Chang-Lun   She Zhi-Gang   Lin Yong-Cheng  

Marine Drugs, Vol. 8, Iss. 4, 2010-03 ,pp. : 941-949 (9)

MDPI

Access to resources Recommend Favorite