Identification of a Novel Human Rhinovirus C Type by Antibody Capture VIDISCA-454

Author: Jazaeri Farsani Seyed Mohammad   Oude Munnink Bas B.   Canuti Marta   Deijs Martin   Cotten Matthew   Jebbink Maarten F.   Verhoeven Joost   Kellam Paul   Loens Katherine   Goossens Herman   Ieven Margareta   van der Hoek Lia  

Publisher: MDPI

E-ISSN: 1999-4915|7|1|239-251

ISSN: 1999-4915

Source: Viruses, Vol.7, Iss.1, 2015-01, pp. : 239-251

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.

Related content