Author: Mrejen Sarah Jung Jesse J. Chen Christine Patel Samir N. Gallego-Pinazo Roberto Yannuzzi Nicolas Xu Luna Marsiglia Marcela Boddu Sucharita Freund K. Bailey
Publisher: MDPI
E-ISSN: 2077-0383|4|7|1380-1402
ISSN: 2077-0383
Source: Journal of Clinical Medicine, Vol.4, Iss.7, 2015-07, pp. : 1380-1402
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
With the advent of anti-vascular endothelial growth factor (VEGF) therapy, clinicians are now focused on various treatment strategies to better control neovascular age-related macular degeneration (NVAMD), a leading cause of irreversible blindness. Herein, we retrospectively reviewed consecutive patients with treatment-naïve NVAMD initially classified based on fluorescein angiography (FA) alone or with an anatomic classification utilizing both FA and optical coherence tomography (OCT) and correlated long-term visual outcomes of these patients treated with an anti-VEGF Treat-and-Extend Regimen (TER) with baseline characteristics including neovascular phenotype. Overall, 185 patients (210 eyes) were followed over an average of 3.5 years (range 1–6.6) with a retention rate of 62.9%, and visual acuity significantly improved with a TER that required a mean number of 8.3 (±1.6) (± standard deviation) intravitreal anti-VEGF injections/year (range 4–13). The number of injections and the anatomic classification were independent predictors of visual acuity at 6 months, 1, 2, 3 and 4 years. Patients with Type 1 neovascularization had better visual outcomes and received more injections than the other neovascular subtypes. There were no serious adverse events. A TER provided sustained long-term visual gains. Eyes with Type 1 neovascularization had better visual outcomes than those with other neovascular subtypes.
Related content
By Parmeggiani Francesco Costagliola Ciro Semeraro Francesco Romano Mario R Rinaldi Michele Gallenga Carla Enrica Serino Maria Luisa Incorvaia Carlo D’Angelo Sergio De Nadai Katia Dell’Omo Roberto Russo Andrea Gemmati Donato Perri Paolo
International Journal of Molecular Sciences, Vol. 16, Iss. 8, 2015-08 ,pp. :
By Lai Yan-Da Wu Yen-Yu Tsai Yi-Jiue Tsai Yi-San Lin Yu-Ying Lai Szu-Liang Huang Chao-Yang Lok Ying-Yung Hu Chih-Yung Lai Jiann-Shiun
International Journal of Molecular Sciences, Vol. 17, Iss. 2, 2016-02 ,pp. :