Author： Machado Mariana Verdelho Cortez-Pinto Helena
Publisher： MDPI
E-ISSN： 1422-0067|17|4|481-481
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.17, Iss.4, 2016-04, pp. : 481-481
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Recently, the importance of the gut-liver-adipose tissue axis has become evident. Nonalcoholic fatty liver disease (NAFLD) is the hepatic disease of a systemic metabolic disorder that radiates from energy-surplus induced adiposopathy. The gut microbiota has tremendous influences in our whole-body metabolism, and is crucial for our well-being and health. Microorganisms precede humans in more than 400 million years and our guest flora evolved with us in order to help us face aggressor microorganisms, to help us maximize the energy that can be extracted from nutrients, and to produce essential nutrients/vitamins that we are not equipped to produce. However, our gut microbiota can be disturbed, dysbiota, and become itself a source of stress and injury. Dysbiota may adversely impact metabolism and immune responses favoring obesity and obesity-related disorders such as insulin resistance/diabetes mellitus and NAFLD. In this review, we will summarize the latest evidence of the role of microbiota/dysbiota in diet-induced obesity and NAFLD, as well as the potential therapeutic role of targeting the microbiota in this set.
Related content
Access to resources
Recommend
By Del Chierico Federica Gnani Daniela Vernocchi Pamela Petrucca Andrea Alisi Anna Dallapiccola Bruno Nobili Valerio Lorenza Putignani
International Journal of Molecular Sciences, Vol. 15, Iss. 1, 2014-01 ,pp. :
Gene-Diet Interaction and Precision Nutrition in Obesity
International Journal of Molecular Sciences, Vol. 18, Iss. 4, 2017-04 ,pp. :
Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
By Garcia-Contreras Consolacion Vazquez-Gomez Marta Torres-Rovira Laura Gonzalez Jorge Porrini Esteban Gonzalez-Colaço Magali Isabel Beatriz Astiz Susana Gonzalez-Bulnes Antonio
International Journal of Molecular Sciences, Vol. 19, Iss. 3, 2018-03 ,pp. :