Synthesis, Anti-HCV, Antioxidant and Reduction of Intracellular Reactive Oxygen Species Generation of a Chlorogenic Acid Analogue with an Amide Bond Replacing the Ester Bond †

Author： Wang Ling-Na   Wang Wei   Hattori Masao   Daneshtalab Mohsen   Ma Chao-Mei  

Publisher： MDPI

E-ISSN： 1420-3049|21|6|737-737

ISSN： 1420-3049

Source： Molecules, Vol.21, Iss.6, 2016-06, pp. : 737-737

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Abstract

Chlorogenic acid is a well known natural product with important bioactivities. It contains an ester bond formed between the COOH of caffeic acid and the 3-OH of quinic acid. We synthesized a chlorogenic acid analogue, 3α-caffeoylquinic acid amide, using caffeic and quinic acids as starting materials. The caffeoylquinc acid amide was found to be much more stable than chlorogenic acid and showed anti-Hepatitis C virus (anti-HCV) activity with a potency similar to chlorogenic acid. The caffeoylquinc acid amide potently protected HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide.

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