Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

Author： Yang Bing-You   Zhang Jing   Liu Yan   Kuang Hai-Xue  

Publisher： MDPI

E-ISSN： 1420-3049|21|8|1075-1075

ISSN： 1420-3049

Source： Molecules, Vol.21, Iss.8, 2016-08, pp. : 1075-1075

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Abstract

Four new steroid saponins 1–4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively.

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