In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Author: Leliebre-Lara Vivian   Monzote Fidalgo Lianet   Pferschy-Wenzig Eva-Maria   Kunert Olaf   Nogueiras Lima Clara   Bauer Rudolf  

Publisher: MDPI

E-ISSN: 1420-3049|21|8|1045-1045

ISSN: 1420-3049

Source: Molecules, Vol.21, Iss.8, 2016-08, pp. : 1045-1045

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Abstract

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.

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