Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

Author: Alexandre-Gouabau Marie-Cécile   Moyon Thomas   Cariou Véronique   Antignac Jean-Philippe   Qannari El Mostafa   Croyal Mikaël   Soumah Mohamed   Guitton Yann   David-Sochard Agnès   Billard Hélène   Legrand Arnaud   Boscher Cécile   Darmaun Dominique   Rozé Jean-Christophe   Boquien Clair-Yves  

Publisher: MDPI

E-ISSN: 2072-6643|10|2|164-164

ISSN: 2072-6643

Source: Nutrients, Vol.10, Iss.2, 2018-01, pp. : 164-164

Access to resources Favorite

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.

Related content