Author： Yuan Chengfu Han Yaping Zellmer Lucas Yang Wenxiu Guan Zhizhong Yu Wenfeng Huang Hai Liao D. Joshua
Publisher： MDPI
E-ISSN： 1422-0067|18|4|714-714
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.18, Iss.4, 2017-03, pp. : 714-714
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Abstract
There have been tens of thousands of RNAs deposited in different databases that contain sequences of two genes and are coined chimeric RNAs, or chimeras. However, “chimeric RNA” has never been lucidly defined, partly because “gene” itself is still ill-defined and because the means of production for many RNAs is unclear. Since the number of putative chimeras is soaring, it is imperative to establish a pellucid definition for it, in order to differentiate chimeras from regular RNAs. Otherwise, not only will chimeric RNA studies be misled but also characterization of fusion genes and unannotated genes will be hindered. We propose that only those RNAs that are formed by joining two RNA transcripts together without a fusion gene as a genomic basis should be regarded as authentic chimeras, whereas those RNAs transcribed as, and
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