Author： Cheng Zhengyuan Limbu Manoj Hang Wang Zhi Liu Jing Liu Lei Zhang Xiaoyi Chen Pingsheng Liu Bicheng
Publisher： MDPI
E-ISSN： 1422-0067|18|4|776-776
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.18, Iss.4, 2017-04, pp. : 776-776
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation are closely related to the cell signaling pathways, hypoxia and cell membrane structural change. Gelatinases also can affect the development and progression of CKD through the various interactions with tumor necrosis factors (TNFs), monocyte chemoattractant proteins (MCPs), growth factors (GFs), oxidative stress (OS), and so on. Currently, their non-proteolytic function is a hot topic of research, which may also be associated with the progression of CKD. Therefore, with the in-depth understanding about the function of gelatinases, we can have a more specific and accurate understanding of their role in the human body.
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