Author： Sarr Ousseynou Strohm Rachel Joyce MacDonald Tara Lynn Gaudio Nicholas Reed John Kenneth Foute-Nelong Jules Dyck David James Mutch David Michael
Publisher： MDPI
E-ISSN： 1422-0067|18|5|959-959
ISSN： 1422-0067
Source： International Journal of Molecular Sciences, Vol.18, Iss.5, 2017-05, pp. : 959-959
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Abstract
Adipose tissue plays a key role in the development of type-2 diabetes via the secretion of adipokines. The current study investigated if secretion media derived from intact visceral (VAT) and subcutaneous (SAT) adipose tissues from extremely obese men and women differently suppressed insulin signaling in human skeletal myotubes derived from a healthy, non-diabetic male and female donor, respectively. Adipose tissue samples were collected from men and women during laparoscopic bariatric surgery. In general, secretion media collected from both SAT and VAT depots caused impaired insulin signaling in myotubes, independent of sex. In females, this was true regardless of the protein kinase B (Akt) phosphorylation site (Akt Thr308 and Akt Ser473) assessed (
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