A Rapid Protocol to Synthesize γ-Butyrolactone Derivatives via the Microwave Technique

Publisher： Bentham Science Publishers

ISSN： 2213-3356

Source： Current Microwave Chemistry, Vol.2, Iss.1, 2015-04, pp. : 83-87

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Abstract

This work reports the synthesis of several 3-methoxycarbonyl-γ-butyrolactone derivatives (4-12) starting from dimethyl itaconate (1), an aryl bromide (2), and a carbonyl compound (3). The synthetic protocol used microwave irradiation, argon atmosphere, and acetonitrile as solvent. The synthesis furnished the target compounds in 80-96% yield; reactions lasted about 10-20 min.

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