Publisher： John Wiley & Sons Inc
E-ISSN： 1521-4095|27|42|6637-6643
ISSN： 0935-9648
Source： ADVANCED MATERIALS, Vol.27, Iss.42, 2015-11, pp. : 6637-6643
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Abstract
New protein nanocages are designed bearing two functional proteins, γ‐carboxyglutamic acid of protein C (PC‐Gla) and thrombin receptor agonist peptide (TRAP), and have an anti‐septic response. These nanoparticles reduce sepsis‐induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
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