Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3773|54|48|14442-14446
ISSN： 1433-7851
Source： ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.48, 2015-11, pp. : 14442-14446
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Abstract
AbstractThe dynamic planar chirality in a peptide‐bound NiII‐salphen‐based macrocycle can be remotely controlled. First, a right‐handed (P)‐310‐helix is induced in the dynamic helical oligopeptides by a chiral amino acid residue far from the macrocyclic framework. The induced planar chirality remains dynamic in chloroform and acetonitrile, but is almost completely locked in fluoroalcohols as a result of the solvent‐induced transition of the peptide chains from a 310‐helix to a wider α‐helix, which freezes the rotation of the pendant peptide units around the macrocycle.
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