Cu(OAc)2/TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines

Publisher： John Wiley & Sons Inc

E-ISSN： 1861-471x|13|1|46-54

ISSN： 1861-4728

Source： CHEMISTRY - AN ASIAN JOURNAL, Vol.13, Iss.1, 2018-01, pp. : 46-54

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Abstract

AbstractA novel and efficient Cu(OAc)2‐catalyzed hydroamination cyclization and 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)‐mediated oxidative dehydrogenation cascade reaction of homopropargylic amines has been developed. A library of 1,2‐disubstituted pyrrole derivatives were obtained in good‐to‐high yields in one pot with no step‐by‐step feeding process. This reaction involved TEMPO playing dual roles as both an oxidative dehydrogenation reagent and a ligand. An insight into the reaction mechanism was obtained by using several analytical determination methods.

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