Publisher： John Wiley & Sons Inc
E-ISSN： 1943-5193|55|1|65-76
ISSN： 0022-152x
Source： JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol.55, Iss.1, 2018-01, pp. : 65-76
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Abstract
Considering quinoxaline as a privileged structure for developing probes of impressive therapeutic potentials, some new azole and azine conjugates of quinoxaline were synthesized. Thus, ethyl 3‐amino‐1,4‐dihydroquinoxaline‐2‐carboxylate (2) was prepared as one‐pot three‐component product and incorporated in a series of manipulations including cyclocondensation reactions to afford a series of pharmacophoric motif conjugates 8–12, 14, 15–17, 20–23, 24–29, 30–37, and 38–43 in fair yields. The newly synthesized were characterized by IR, 1H NMR, 13C NMR, and mass spectral data.
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