One‐Pot Synthesis of Hydroxy Pyrazolo[1,2‐a][1,2,4]triazoles and Their Dehydration Using Recyclable Ionic Liquids as Reaction Media

Publisher： John Wiley & Sons Inc

E-ISSN： 1943-5193|55|1|83-90

ISSN： 0022-152x

Source： JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol.55, Iss.1, 2018-01, pp. : 83-90

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

An eco‐friendly, simple, and efficient one‐pot new procedure has been developed for the synthesis of hydroxy phenylhexahydropyrazolo[1,2‐a][1,2,4]triazoles by condensation of 4‐phenylurazole, aldehydes, and ethyl/methyl acetoacetate using ionic liquid [bmim]BF4 in presence of l‐proline at 80°C. The hydroxy pyrazolo[1,2‐a][1,2,4]triazoles could be dehydrated in presence of [bmim]HSO4 to give corresponding phenyltetrahydropyrazolo[1,2‐a][1,2,4]triazoles in high yields. High yields, less reaction time, operational simplicity, and recyclability of reaction media are the advantages of this protocol.

Related content

One-pot three-component Biginelli-type reaction catalyzed by ionic liquids in aqueous media

By Fang Dong   Zhang Dai-zhen   Liu Zu-liang  

Monatshefte für Chemie / Chemical Monthly, Vol. 141, Iss. 4, 2010-04 ,pp. : 419-423 (5)

Springer Publishing Company

Access to resources Recommend Favorite

Ionic Liquid Promoted One-Pot Three-Component Reaction: Synthesis of Annulated Imidazo[1,2-a]azines Using Trimethylsilylcyanide

By Shaabani Ahmad   Maleki Ali  

Monatshefte für Chemie / Chemical Monthly, Vol. 138, Iss. 1, 2007-01 ,pp. : 51-56 (6)

Springer Publishing Company

Access to resources Recommend Favorite

One-pot Synthesis of Novel 2-pyrazolo-3-phenyl-1,3-thiazolidine-4-ones Using DSDABCOC as an Effective Media

By  

Combinatorial Chemistry & High Throughput Screening, Vol. 21, Iss. 1, 2018-03 ,pp. : 65-69 (5)

Bentham Science Publishers

Access to resources Recommend Favorite

One‐Pot Three‐Component Synthesis of Hantzsch 1,4‐Dihydropyridines Promoted by Dimethyl Phosphate Ionic Liquids

By  

HELVETICA CHIMICA ACTA, Vol. 98, Iss. 8, 2015-08 ,pp. : 1095-1103 (9)

John Wiley & Sons Inc

Access to resources Recommend Favorite

One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media

By  

Combinatorial Chemistry & High Throughput Screening, Vol. 16, Iss. 10, 2013-12 ,pp. : 845-850 (6)

Bentham Science Publishers

Access to resources Recommend Favorite