Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis

E-ISSN： 1872-034x|48|3|E275-E282

ISSN： 1386-6346

Source： HEPATOLOGY RESEARCH, Vol.48, Iss.3, 2018-02, pp. : E275-E282

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Abstract

AimWe aimed to investigate sleep quality, mild hepatic encephalopathy, anxiety, and depression in patients with hepatitis B cirrhosis by using a variety of scales and questionnaires.

MethodA cohort of 341 patients with hepatitis B liver cirrhosis were categorized by Child–Pugh grading (A, B, and C) in this cross‐sectional study. Pittsburgh Sleep Quality Index (PSQI), Number Connection Test‐A (NCT‐A), and Hospital Anxiety and Depression (HAD) evaluated the questionnaires and statistically analyzed the intrinsic correlation. The control group included 50 healthy individuals. Of 341 patients, 213 had a PSQI index >5 points.

ResultsThe PSQI, NCT‐A, anxiety scale (HAD [a]), and depression scale (HAD [d]) of the patients were significantly different. The NCT‐A‐positive patients revealed 214 cases of possible minimal hepatic encephalopathy (MHE) during a preliminary screening of patients. The PSQI score of NCT‐A‐positive patients was significantly elevated compared to NCT‐A‐negative patients (P < 0.001). HAD (a) and HAD (d) were significantly different between the NCT‐A‐positive and NCT‐A‐negative groups (P = 0.002 and P = 0.006, respectively). Univariate Pearson's correlation analysis found that NCT‐A and HAD (a) were positively correlated with PSQI (P < 0.001 and P = 0.045, respectively); however, Child–Pugh score and HAD (d) were not correlated with PSQI (P = 0.061 and P = 0.059, respectively).

ConclusionThese results indicated that patients with hepatitis B liver cirrhosis have a disturbed sleep, which might be an MHE symptom, further causing considerable anxiety. Thus, the evaluation of sleep quality and psychological state of patients with hepatitis B liver cirrhosis necessitates further investigation to guide positive intervention.