Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3765|24|7|chem.201880764-chem.201880764
ISSN： 0947-6539
Source： CHEMISTRY - A EUROPEAN JOURNAL, Vol.24, Iss.7, 2018-02, pp. : n/a-n/a
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The artificial nucleosyl amino acid (NAA) internucleoside linkage was used to construct cationic oligonucleotide analogues. Corresponding oligomers hybridized to native DNA with high affinity. Using melting temperature experiments and CD spectroscopy, it was shown that Watson–Crick base pairing was crucial for this duplex formation, but unspecific electrostatic binding also contributed. These results indicate that the number of positive charges in oligonucleotide analogues for biomedical applications should be limited. For more information, see the Full Paper by T. N. Grossman, C. Ducho, et al. on page 1544 ff.
Related content
Access to resources
Recommend
