Synthesis and Characterization of Chalcone‐Pyridinium Hybrids as Potential Anti‐Cancer and Anti‐Microbial Agents

E-ISSN： 2365-6549|3|5|1424-1431

ISSN： 2365-6549

Source： ChemistrySelect, Vol.3, Iss.5, 2018-02, pp. : 1424-1431

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Abstract

AbstractA series of pyridinium salts (5 a‐p) have been synthesized and were screened for their in vitro anticancer activity against MCF‐7 (breast cancer), HeLa (cervical cancer), U‐87MG (human glioblastoma) and HEK293 (Human Embryonic Kidney 293 cells) cell lines by taking doxorubicin as a positive control. The compounds derived from 4‐methoxyphenyl (5 c) and 4‐nitrophenyl (5 h) have showed significant and broad spectrum antiproliferative activity against the tested cancer cell‐lines and also displayed potential in vivo against Ehrlich ascites carcinoma (EAC) in mice. Also, screened the compounds for their antimicrobial and anti‐acetylcholinesterase (anti‐AchE) activities. It was observed form the in vitro results that, compounds derived from 4‐methylphenyl (5 b), 4‐chlorophenyl (5 f), coumarinyl (5 i) and napthyl (5 j) have exhibited potential antibacterial activity against Staphylococcus aureus and the derivatives 5 b and 4‐fluorophenyl (5 e) have showed promising antifungal activity and the compound 5 c showed moderate AChE inhibitory activity.