Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors - effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding

Author： Fraley M.E.   Arrington K.L.   Buser C.A.   Ciecko P.A.   Coll K.E.   Fernandes C.   Hartman G.D.   Hoffman W.F.   Lynch J.J.   McFall R.C.   Rickert K.   Singh R.   Smith S.   Thomas K.A.   Wong B.K.  

Publisher： Elsevier

ISSN： 0960-894X

Source： Bioorganic and Medicinal Chemistry Letters, Vol.14, Iss.2, 2004-01, pp. : 351-355

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