Phosphoramidate derivatives of acyclovir, inhibitors of herpes virus replication

Author： Zakirova N.   Shipitsyn A.   Jasko M.   Kochetkov S.  

Publisher： MAIK Nauka/Interperiodica

ISSN： 1068-1620

Source： Russian Journal of Bioorganic Chemistry, Vol.37, Iss.5, 2011-09, pp. : 578-585

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Abstract

A series of new acyclovir phosphoramidates—potential antiviral agents against resistant strains of herpes virus—was synthesized. Of several approaches used for their synthesis, the treatment of the intermediate phosphorochloridate with various amines proved to be optimal. Two of the synthesized compounds were moderately active against HSV-1.

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