Author: Lages Eduardo Burgarelli de Freitas Maria Betânia Gonçalves Isadora Marques Brum Alves Ricardo José Vianna-Soares Cristina Duarte Ferreira Lucas Antônio Miranda de Oliveira Mônica Cristina de Oliveira Renata Barbosa
Publisher: American Scientific Publishers
ISSN: 1550-7033
Source: Journal of Biomedical Nanotechnology, Vol.9, Iss.11, 2013-09, pp. : 1939-1944
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Abstract
Nitroheterocyclic compounds have received considerable interest as hypoxia-selective cytotoxins (HSC) for cancer treatment. In the present study, we investigated antitumor activity of an iodide analogue of metronidazole, 1-(2-iodoethyl)-2-methyl-5-nitroimidazole (MTZ-I), using Swiss mice bearing solid Ehrlich tumor. MTZ-I showed potent anti-cancer activity at a dose of 40 mg/kg. MTZ-I loaded solid lipid nanoparticles (SLN) were developed as an alternative colloidal carrier system to enhance tumor drug uptake. SLN were characterized for particle size, polydispersity index, zeta potential and entrapment efficiency. In addition, the influence of presence of the cationic lipid stearylamine (STE) on stability of formulation was assessed. The results of DSC study showed that MTZ-I exhibited interaction with STE.
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