Carbon-Based Nanoparticles and Innate Immune Responses in the Brain

Author: Campbell Arezoo   Wang Kate  

Publisher: American Scientific Publishers

ISSN: 1939-0637

Source: Journal of Nanoneuroscience, Vol.1, Iss.2, 2009-12, pp. : 116-119

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Abstract

The rapid progression of nanotechnology has opened limitless possibilities for the use of highly organized nanosized particles as medical tools and devices. Although the field is rapidly developing, not much is known about the potential toxicity of various carbon-based nanomaterials. Chronic immune responses to such compounds may pose a potential harm to humans, especially if the particles are not biodegradable or otherwise removable. In the brain, where immunological processes involved in degradation of foreign substances are limited, the removal of nanoparticles may be complicated and slow. In this brief review the possible adverse central nervous system (CNS) effects of carbon-based nanomaterial, with an emphasis on potential neuroinflammatory responses, will be discussed.

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