Spectrum from Obesity to Neurodegenerative Disorder

Author： Diwan. A. Aziz Khan Shahida Rishi Patel Kavita Krishna Firoz C.K. Kamal Mohammad A.

Publisher： American Scientific Publishers

ISSN： 1947-2951

Source： American Journal of Neuroprotection and Neuroregeneration, Vol.4, Iss.1, 2012-10, pp. : 31-39

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Abstract

Background-Obesity being a continuously increasing problem and one of the leading causes of mortality is affecting the urban population of the globe rapidly. While adverse health complications leading to morbidity need to be screened early as a preventive measure, the consequences of obesity on the cardiovascular system, endocrine system, and CNS also needs to be reviewed. Increasing evidence on loss of cognition due to obesity makes us look at the complications which could have far reaching physical as well as mental health implications. Aim-To assess the prevalence of various co-morbidities associated with obesity leading to CNS degeneration. Settings and Design-A total of 100 overweight and obese individuals, apparently asymptomatic were included in the study with 64 males and 36 females in the age group16 yrs to 75 yrs. Based on their increasing BMI, these hundred obese subjects with a body mass index (BMI) above 25 Kg/m² and without known obesity related disorders were put into three different groups. Materials and Methods. All the subjects selected underwent tests like blood pressure (BP), electro cardiogram (ECG), ultra sonography (USG) abdomen and were also checked for musculo-skeletal complaints. Blood sugar and lipid profile were estimated using standardized procedures. The study was duly approved by the institutional ethical committee. Statistical analysis was done using Microsoft Excel sheet. Results and Conclusions-Complications due to obesity are very much prevalent making them potential candidates for CNS disorders too. Complications were observed in all the obese subjects studied viz; hypertension prehypertension, dyslipidemia, diabetes mellitus, cholelithiasis, osteoarthritis and obstructive sleep apnea. Statistical analysis indicated an association between systolic blood pressure, diastolic blood pressure, cholesterol, and triglycerides with obesity in varying degrees. Many screened were asymptomatic. Therefore it is necessary that early screening be done in obese patients to avoid potent risk factors for various complications.