Author： Spingler Bernhard Da Pieve Chiara Medina-Molner Alfredo Antoni Philipp M. Santangelo Maria Grazia
Publisher： Swiss Chemical Society
ISSN： 0009-4293
Source： CHIMIA International Journal for Chemistry, Vol.63, Iss.3, 2009-03, pp. : 153-156
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.
Related content
APPLIED ORGANOMETALLIC CHEMISTRY (ELECTRONIC), Vol. 32, Iss. 3, 2018-03 ,pp. :
Access to resources
Recommend
By Yang Yan Yan Liu-Ting Luo Xu-Jian Zhu Yu-Lin Qin Rong-Huan Jiang Yue-Xiu Liang Wei-Jiang
Supramolecular Chemistry, Vol. 25, Iss. 7, 2013-07 ,pp. :