The Apelin/APJ System: From Vascular Biology to Heart Failure

Author: Francia Pietro  

Publisher: Adis International

ISSN: 1120-9879

Source: High Blood Pressure & Cardiovascular Prevention, Vol.13, Iss.4, 2006-01, pp. : 159-162

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Apelin, the endogenous ligand of the G protein-coupled APJ receptor, displays several activities on the cardiovascular system. Indeed, recent studies support the notion that the apelin/APJ system is involved in key mechanisms that are relevant to fluid homeostasis, blood pressure control and cardiac contractility. This paper reviews our current knowledge on the physiological properties and potential clinical significance of apelin and APJ receptor.Received for publication 18 October 2006; accepted for publication 22 October 2006.